RAK3172 using PB12 as GPIO output limitations?

Using RUI 4.2.0 with RAK3172 (US915 version), are there any startup or timing limitations (e.g. startup definition of PB12 pin as an output and a digitalWrite to a high/low level) when using PB12 as an output GPIO?
Is it a problem if circuitry attached to PB12 may pull the pin low at startup.

Also, if a pin’s hex value is to be used when defining pins with pinMode, please share the documentation link to the pins hex value.

RAK3172 Pin definition

If PB12 is pulled low during bootup, the RAK3172 thinks it is a EU433 or CN470 device and will not allow you to set any LoRaWAN region with 8xx or 9xx MHz or, if LoRa P2P to set any frequency higher than 470MHz.

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